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AM 2201 is a synthetic cannabinoid that has been around since the early 2000s. The drug is also known as NNE1 and AM2233, but it is most commonly sold under the name “AM 2201”. This psychoactive substance has gained popularity amongst researchers because of its ability to treat anxiety disorders and other mental health conditions. The drug has also been used in the treatment of insomnia, ADHD and chronic pain.
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AM 2201 is a synthetic cannabinoid receptor agonist that has been used as an active ingredient in the research and development of new drugs.
AM 2201 is one of the most potent and selective agonists for CB2 receptors with an EC50 value of 0.09 nM against human CB2 receptors. This compound shows very high selectivity over CB1 receptors (EC50 = 539 nM).
AM 2201 (also known as SR-19 and STS-135) is a designer drug that acts as a potent agonist for the cannabinoid receptors, with a binding affinity of 0.23nM at CB2 receptors and 0.26nM at CB1 receptors. It was discovered in 2005 by Alexandros Makriyannis and colleagues at Northeastern University who were searching for novel CB1 receptor agonists to study their role in modulating synaptic transmission.
AM 2201 has been shown to produce effects similar to those produced by THC (e.g., hypothermia and analgesia) in animal studies, although its potency is significantly lower than THC (pKB = 11.3 compared to 9.3). Unlike THC it does not appear to induce catalepsy or modify body temperature when administered acutely. AM 2201 also produces antidepressant effects in mice, which may be due to its partial agonist activity at 5HT1A receptors.
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However, AM 2201 has been shown to be much more potent than THC at activating D9-THC receptors. This receptor is believed to play an important role in neurodegeneration caused by Alzheimer
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